IgM, IgG Serum Levels and Lymphocytes Count before and after Adenotonsillectomy.
نویسندگان
چکیده
BACKGROUND Tonsils and adenoids are involved in both local immunity and immune surveillance for the development of immune defence mechanisms. A number of investigators have found decreased immunoglobulin levels after adenotonsillectomy while others have failed to find significant changes. The effects of adenotonsillectomy on the cellular immunity of children have not been investigated extensively. OBJECTIVE To observe the change in humeral and cellular immune systems before and after operation in patients undergoing adenotonsillectomy. METHODS The study comprised 102 patients; all of the patients underwent adenotonsillectomy. The levels of IgG, IgA, and IgM were measured for humoral immunity and the percent of CD7 and CD19 positive cells were determined in blood samples taken from these patients 24 hours before operation and also 2 and 8 weeks after the operation. The results were subjected to statistical analysis. RESULTS The present study shows that the serum level of IgA would raise few weeks after the operation. Changes in the IgM and IgG level were not statistically significant postoperatively. In addition, no significant change was detected in B lymphocyte count before and after adenotonsillectomy.In our study, there was a slight decrease in the T lymphocyte count in the early stage of post operation, which returned to normal preoperative value after 8 weeks. CONCLUSION Several immune system parameters maintain its normal status several weeks after adenotonsillectomy.
منابع مشابه
IgM, IgG, IgA Serum Levels and Lymphocytes Count Before and After Adenotonsillectomy
Background: Tonsils and adenoids are involved in both local immunity and immune surveillance for the development of immune defense mechanisms. A number of investigators have found decreased immunoglobulin levels after adenotonsillectomy while others have failed to find significant changes. The effects of adenotonsillectomy on the cellular immunity of children have not been investigated extensiv...
متن کاملبررسی وضعیت سیستم ایمنی هومورال و سلولی کودکان قبل و بعد از عمل آدنوتونسیلکتومی
Background and Aim: Adenoids and tonsils are active lymphoid organs and playing an important role against invading antigens of upper aero digestive tract in children. The purpose of this study is observing the changes in cellular and humoral immunity of children six months after adenotonsillectomy. Materials and Methods: The study population consisted of 30 children (aged 4-10 years) with chron...
متن کاملبررسی غلظت گروه و زیرگروههای ایمنوگلوبولین و فنوتیپ لنفوسیتی در کودکان قبل و بعد از عمل برداشت آدنویید و لوزهها در مرکز تحقیقات گوش و حلق و بینی و سر و گردن بیمارستان حضرت رسول اکرم(ص)
Background & Aim: Chronic infection of tonsils in childhood is a leading cause of adeno-tonsillectomy. A question has been asked for a long time to find out whether there is any risk of immune impairment after adenotonsillectomy. Therefore, the present study was undertaken to evaluate immunologic parameters in children before and after adenoidectomy. Patients & Methods: In this cohort study...
متن کاملHumoral and Cellular Immunity Parameters in Children before and after Adenotonsillectomy
Adenoids and tonsils are active lymphoid organs and play an important role against invading antigens of upper aerodigestive tract in children. The present study analyzes the changes in cellular and humoral immunity of children six months after adenotonsillectomy. The study population consisted of 30 children whit chronic adenotonsillar hypertrophy and 30 age-matched healthy children. In all chi...
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ورودعنوان ژورنال:
- Iranian journal of immunology : IJI
دوره 3 4 شماره
صفحات -
تاریخ انتشار 2006